A step-down protocol for omalizumab treatment in oral corticosteroid-dependent allergic asthma patients
نویسندگان
چکیده
منابع مشابه
Reduction in oral corticosteroid use in patients receiving omalizumab for allergic asthma in the real-world setting
BACKGROUND Oral corticosteroids (OCS) are commonly administered in patients with severe persistent allergic asthma. Despite their efficacy, they are associated with a wide variety of adverse events. The eXpeRience registry was set up to investigate real-world outcomes among patients receiving omalizumab for the treatment of uncontrolled allergic asthma. Here, we present the effect of omalizumab...
متن کاملReduction in oral corticosteroid use in patients with severe allergic (IgE-mediated) asthma receiving omalizumab in a real-world setting
Background Patients with severe allergic asthma (SAA) are often inadequately controlled despite available treatments including high-dose inhaled corticosteroids and longacting b2-agonists. Use of oral corticosteroids (OCS) in SAA patients may not achieve full asthma control, and leads to significant long-term side effects. Omalizumab is a recombinant humanized monoclonal anti-immunoglobulin E (...
متن کاملEffectiveness of Omalizumab in Reducing Corticosteroid Burden in Patients With Moderate to Severe Persistent Allergic Asthma
STUDY POPULATION. Patients (N 1071) were aged 12 to 75 years with moderate-to-severe persistent allergic asthma that was inadequately controlled with ICSs. Eight percent of the patients were aged 12 to 18 years. All patients had confirmed allergic asthma, an immunoglobulin E (IgE) level between 30 and 700 IU/mL, and a baseline forced expiratory volume in 1 second (FEV1) between 40% and 80%. Dat...
متن کاملOmalizumab reduces corticosteroid use in patients with severe allergic asthma: real-life experience in Israel.
OBJECTIVE Approved by the FDA in 2003, omalizumab is the first recombinant humanized monoclonal anti-immunoglobulin E antibody developed for the treatment of allergic asthma. Due to the heterogeneity of asthma symptoms, investigation of the efficacy of omalizumab in patients outside controlled trials is particularly important. The purpose of the current study was to evaluate the efficacy of oma...
متن کاملEffectiveness of omalizumab in reducing corticosteroid burden in patients with moderate to severe persistent allergic asthma.
BACKGROUND Asthma guidelines advocate maintaining asthma control while minimizing corticosteroid exposure. OBJECTIVE To assess the reduction in corticosteroid burden during long-term treatment and the corresponding impact of this reduction on asthma control, lung function, and inflammation in patients with moderate to severe allergic asthma. METHODS We conducted a pooled analysis (N = 1,071...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2017
ISSN: 0306-5251
DOI: 10.1111/bcp.13453